Stem cells are cells that have the unique ability to self-renew and to transform into many specialized cell types. They can be isolated either from embryos or from adult tissue. Adult stem cells are being used for various medical therapies in which they are grown and differentiated into different cell types, and then introduced into…
Read MoreC3 awards research grant to Dr. Rita Perlingeiro to develop gene editing strategy for LGMD2A
Coalition to Cure Calpain 3 (C3) is excited to announce that we are funding a new research project with Dr. Rita Perlingeiro, Professor of Medicine and Lillehei Professor in Stem Cell and Regenerative Cardiovascular Medicine at the University of Minnesota. The project is titled “Gene editing of Calpain 3 in LGMD2A iPS cells.” There has been tremendous…
Read MoreC3 Awards Grant to Dr. Melissa Spencer to Screen for Calpain 3 Targets
Coalition to Cure Calpain 3 (C3) is excited to announce that we are funding a new research project with Dr. Melissa Spencer at the University of California Los Angeles. The project is titled “Identification of calpain 3 substrates through use of 2D DIGE and mass spectrometry, and testing muscle-building compounds in an LGMD2A model.” Identification of calpain 3…
Read MoreC3 supports generation of new LGMD2A disease model for research
C3 is excited to announce that we are funding a research project with Dr. Cathleen Lutz, Director of the Rare and Orphan Disease Center at The Jackson Laboratory in Bar Harbor, Maine. Dr. Lutz works with researchers and disease foundations in the development, characterization and validation of mouse models. These models can then be distributed…
Read MoreC3 Lends Support to New Initiative in Genetic Testing for LGMD2A Patients
Coalition to Cure Calpain 3 is excited to announce that we are funding the MYO-SEQ project at the John Walton Muscular Research Centre at Newcastle University (UK). We are partnering with several patient organizations and biopharmaceutical companies to support this program, which collaborates with the Broad Institute of Harvard and MIT to apply whole exome…
Read More