C3 is pleased to share that a research grant has been awarded to Drs. Ana Töpf, Jordi Diaz-Manera, and Volker Straub at the John Walton Muscular Dystrophy Research Centre at Newcastle University. This project, titled “Understanding the variable expression of dominant calpainopathies,” explores the molecular basis for LGMDD4, also known as dominant calpainopathy. The Challenges…
Read MoreNew Research Grant: Solving the structure of Calpain 3
C3 is delighted to share that a research grant has been awarded to Dr. Peter Davies of Queen’s University in Ontario, Canada. The project, titled “Solving the structure of Calpain 3 and assessing the impact of LGMD2A/R1,” aims to determine the three-dimensional structure of the Calpain 3 enzyme. Further, his lab will investigate how LGMD2A/R1-causing variants impact…
Read MoreNew research grant aims to improve genetic diagnostics in individuals with CAPN3 mutations
C3 is excited to share that a research grant has been awarded to Dr. Svetlana Gorokhova and Dr. Marc Bartoli, Translational Neuromyology Team, Marseille Medical Genetics Institute at Aix Marseille University. The project, “Optimizing the functional assay to identify novel CAPN3 variants responsible for the dominant form of calpainopathy,” will develop a tool to help identify the inheritance patterns of CAPN3 variants….
Read MoreNew Research Grant: Investigating calcium handling modulation as a potential therapeutic for LGMD2A/R1
Coalition to Cure Calpain 3 (C3) is driving LGMD2A/R1 research by awarding a new grant to Dr. Elisabeth Barton, Dr. Lan Wei-LaPierre, and Dr. Siobhan Malany of the University of Florida. The project is titled “Store-operated calcium entry modulation as a potential therapeutic for LGMD2A/R1.” This research is co-funded with the Muscular Dystrophy Association (MDA)….
Read MoreNew Research Grant: Multi-national collaboration aims to identify biomarkers
C3 is pleased to announce the funding of a new research project to Dr. Christopher Heier, of Virginia Commonwealth University in the USA, and Dr. Utkarsh Dang, of Carleton University in Canada. The project is titled “Comparative proteomics of LGMD2A/R1 and Becker muscular dystrophy to develop serum protein biomarkers and predict drug responsiveness in LGMD2A/R1.”…
Read MoreWhat’s new in LGMD2A/R1 research? Posters highlight new research at the International LGMD Conference
The 2025 International LGMD Conference, hosted by the Speak Foundation, was attended by over 500 LGMD patients and family members, clinicians, and scientists. For the first time, the conference included a scientific poster session for researchers to present their basic, translational, or clinical research related to LGMDs. Twenty-five abstracts were selected for presentations, including seven that were…
Read MoreCoalition to Cure Calpain 3 and Muscular Dystrophy Association partner to fund gene therapy grant
Muscular Dystrophy Association (MDA) and Coalition to Cure Calpain 3 (C3) partner to fund $300,000 research grant for gene therapy development in limb-girdle muscular dystrophy. This grant supports the work of Melissa Spencer, PhD, Director of the Neuromuscular Division in Neurology, Co-Director of the Center for Duchenne Muscular Dystrophy and member of the Broad Stem…
Read MoreDr. Stephanie Hunn awarded C3 Travel Grant
Coalition to Cure Calpain 3 (C3) is pleased to announce that Stephanie Hunn DPT was awarded a Travel Grant for the presentation of her research at the Annual Congress of the World Muscle Society in Charleston, South Carolina, from October 3-7, 2023. The goal of the C3 Travel Grant program is to foster early career…
Read MoreC3 funds retrospective analysis of clinical outcome assessments
Coalition to Cure Calpain 3 (C3) is pleased to announce the funding of a new research award to Dr. Meredith James and Professor Jordi Díaz-Manera of the John Walton Muscular Dystrophy Research Centre (JWMDRC) at Newcastle University. The project, titled “Improving clinical trial readiness by investigating the suitability of clinical outcome assessments and documenting the…
Read MoreNew research grant aims to improve genetic diagnoses in individuals with CAPN3 mutations
Coalition to Cure Calpain 3 (C3) is pleased to announce a research grant has been awarded to Dr. Svetlana Gorokhova, working together with Dr. Marc Bartoli in the Translational Neuromyology Team, Marseille Medical Genetics Institute at Aix Marseille University. The project,“A diagnostic functional test to rule out dominant forms of calpainopathy,” will develop a tool to…
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