Coalition to Cure Calpain 3

C3 has a pinpoint focus to drive research toward a treatment or cure for calpainopathy (LGMD2A/R1 and LGMDD4)

For Patients For Researchers For Supporters

Understanding Calpainopathy

Learn more about LGMD2A/R1 and LGMDD4, how these types of limb-girdle muscular dystrophy are diagnosed and inherited, and how you can take part in advancing research

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Advancing the Science

Explore the projects we fund, our grant program, and the toolbox we’re building to speed research and clinical trials in LGMD2A/R1 and LGMDD4

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Fueling Treatments

Your support helps us make a big impact, even with small investments. Discover how you can get involved and help fuel treatments and a cure for calpainopathy (LGMD2A/R1 and LGMDD4).

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Your support helps us fund the most promising scientific research to find treatments and a cure for this rare, muscle-wasting disease

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Dr. Levy to Present at First TREAT-NMD LGMD Masterclass in the US

Advancing Excellence in LGMD Diagnosis, Care, and Emerging Therapies (CME Accreditation) 📅 13-14 November 2026 | 📍 Atlanta, Georgia As new therapies move closer to clinical practice, the need for accurate diagnosis, specialist knowledge, and coordinated multidisciplinary care has never been greater. Developed for healthcare professionals involved in the diagnosis and management of limb-girdle muscular…

Coalition to Cure Calpain 3

For Patients

Understanding Calpainopathy

Understanding Calpainopathy

For Researchers

Advancing the Science

Advancing the Science

For Supporters

Fueling Treatments

Fueling Treatments

Donate Now

Join the Patient Registry

Dr. Levy to Present at First TREAT-NMD LGMD Masterclass in the US

Explore Patient Stories

Discover Our Research