Coalition to Cure Calpain 3

C3 has a pinpoint focus to drive research toward a treatment or cure for calpainopathy (LGMD2A/R1 and LGMDD4)

For Patients For Researchers For Supporters

Understanding Calpainopathy

Learn more about LGMD2A/R1 and LGMDD4, how these types of limb-girdle muscular dystrophy are diagnosed and inherited, and how you can take part in advancing research

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Advancing the Science

Explore the projects we fund, our grant program, and the toolbox we’re building to speed research and clinical trials in LGMD2A/R1 and LGMDD4

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Fueling Treatments

Your support helps us make a big impact, even with small investments. Discover how you can get involved and help fuel treatments and a cure for calpainopathy (LGMD2A/R1 and LGMDD4).

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Your support helps us fund the most promising scientific research to find treatments and a cure for this rare, muscle-wasting disease

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New Research Alert! “The Energy Switch”

A new paper, “CaMKIIβ Signaling drives expression of metabolic and stress response genes in skeletal muscle, and its loss contributes to the LGMDR1 phenotype,” was recently published in the journal Human Molecular Genetics. It was authored by a multi-institutional group led by Dr. Melissa Spencer, C3 Scientific Advisory Board Chair and Professor of Neurology and…

Coalition to Cure Calpain 3

For Patients

Understanding Calpainopathy

Understanding Calpainopathy

For Researchers

Advancing the Science

Advancing the Science

For Supporters

Fueling Treatments

Fueling Treatments

Donate Now

Join the Patient Registry

New Research Alert! “The Energy Switch”

Explore Patient Stories

Discover Our Research