Coalition to Cure Calpain 3

C3 has a pinpoint focus to drive research toward a treatment or cure for calpainopathy (LGMD2A/R1 and LGMDD4)

For Patients For Researchers For Supporters

Understanding Calpainopathy

Learn more about LGMD2A/R1 and LGMDD4, how these types of limb-girdle muscular dystrophy are diagnosed and inherited, and how you can take part in advancing research

Learn More

Advancing the Science

Explore the projects we fund, our grant program, and the toolbox we’re building to speed research and clinical trials in LGMD2A/R1 and LGMDD4

Explore Research

Fueling Treatments

Your support helps us make a big impact, even with small investments. Discover how you can get involved and help fuel treatments and a cure for calpainopathy (LGMD2A/R1 and LGMDD4).

Get Involved

Donate Now

Your support helps us fund the most promising scientific research to find treatments and a cure for this rare, muscle-wasting disease

Fund the Science

Join the Patient Registry

C3 on Capitol Hill: LGMD Day on the Hill 2026

C3 was proudly represented in Washington, D.C. at 2026 LGMD Day on the Hill, hosted by The Speak Foundation. C3 Advocacy Chair Melina Garza was selected as a 2026 delegate and had the privilege of leading the Texas and North Carolina delegation through a packed day of advocacy on Capitol Hill. The day began with…

Coalition to Cure Calpain 3

For Patients

Understanding Calpainopathy

Understanding Calpainopathy

For Researchers

Advancing the Science

Advancing the Science

For Supporters

Fueling Treatments

Fueling Treatments

Donate Now

Join the Patient Registry

C3 on Capitol Hill: LGMD Day on the Hill 2026

Explore Patient Stories

Discover Our Research