LGMD2A/R1 & LGMDD4

The limb-girdle muscular dystrophies (LGMD) are a group of genetically inherited, progressive, muscle-wasting diseases. Collectively, LGMD2A/R1 and LGMDD4 are called calpainopathy.

Calpainopathy is a genetically inherited condition, and the age when symptoms begin can vary. Explore the signs and symptoms of calpainopathy.

C3 encourages all patients to obtain a genetic diagnosis. Find out how calpainopathy is diagnosed. There are two ways that this rare disease can be inherited. Learn more about the inheritance patterns of LGMD2A/R1 and LGMDD4.

Drug development for rare diseases is a long and expensive process. Discover how C3 works to accelerate drug development and accelerate the likelihood of an approved treatment for LGMD2A/R1 and LGMDD4.

Get to know the C3 community and learn more about calpainopathy through the stories and experiences of those living with this muscle-wasting disease.

Coalition to Cure Calpain 3 has published a list of answers to frequently asked questions about LGMD2A/R1 and LGMDD4. Find answers and resources.