Category: Grant Announcements

Coalition to Cure Calpain 3 (C3) is pleased to announce the funding of a new research award to Dr. Pia Elustondo of AGADA Biosciences. This project will characterize a novel LGMD2A/R1 disease model and utilize this model to test several candidate drugs. Preclinical drug screening is one of the critical initial steps to develop new…

Coalition to Cure Calpain 3 (C3) is driving LGMD2A/R1 research by awarding a new grant to Dr. Elisabeth Barton and Dr. Lan Wei-LaPierre of the University of Florida. The project is titled “Strategies to improve calcium handling in LGMD2A/R1.” LGMD2A/R1 is caused by mutations in the gene for Calpain 3. Researchers do not fully understand…

Coalition to Cure Calpain 3 (C3) is delighted to announce a newly-funded research grant to develop a gene therapy for LGMD2A/R1 using vectors optimized for gene delivery to muscles most affected by the disease. This work involves a multi-lab collaboration between Dr. Melissa Spencer at the University of California Los Angeles and Drs. Jeffrey Chamberlain…

Coalition to Cure Calpain 3 (C3) is celebrating the New Year with a new research grant! We are pleased to announce a grant has been awarded to Dr. Antoine Dufour, Assistant Professor of Physiology and Pharmacology at the University of Calgary. The project, titled “Unbiased Systems-wide Investigation of Calpain 3 in Patients with LGMD2A/R1 Using Mass Spectrometry,”…

Coalition to Cure Calpain 3 (C3) is pleased to announce that Dr. Stefanie Müthel was awarded a Travel Grant for the presentation of her research at the Biology of Calpains in Health and Disease Conference in Pacific Grove, California, from July 14-19, 2019. Dr. Müthel is a postdoctoral researcher in the laboratory of Dr. Simone Spuler at…

Coalition to Cure Calpain 3 (C3) is pleased to announce that a research grant has been awarded to Dr. Nicholas Johnson, Associate Professor & Vice Chair of Research, Virginia Commonwealth University. The project is titled “Defining Clinical Endpoints in LGMD.” What are COAs, and why do they matter to those living with LGMD? Clinical outcome assessments (COAs)…

C3 SUPPORTS RESEARCH GROUP FOR NEUROMUSCULAR DISEASES Coalition to Cure Calpain 3 (C3) is pleased to announce that a research grant has been awarded to Dr. Jaakko Sarparanta, researcher at the Research Group for Neuromuscular Diseases led by Dr. Bjarne Udd at Folkhälsan Research Center and Department of Medical Genetics, University of Helsinki, Finland. The project, titled “CAPN3-mediated proteolytic processing of…

Two new research projects funded to explore potential treatments for calpainopathy/LGMD2A $500,000+ committed to gene therapy research since initiative launched in 2017 Coalition to Cure Calpain 3 (C3), a non-profit patient advocacy organization focused on identifying and advancing potential treatments for limb-girdle muscular dystrophy type 2A/calpainopathy (LGMD2A), today announced updates to its Gene Therapy Initiative….

FOURTH GENE THERAPY INITIATIVE GRANT SUPPORTS PROMISING RESEARCH AT NATIONWIDE CHILDREN’S HOSPITAL Coalition to Cure Calpain 3 (C3) is excited to announce that a new research grant has been awarded to Dr. Zarife Sahenk, Professor of Pediatrics and Neurology at Nationwide Children’s Hospital, to assess the safety and efficacy of adeno-associated viral (AAV)-mediated gene therapy in a mouse model…

Coalition to Cure Calpain 3 (C3) is pleased to announce that we are funding a new research grant to Dr. Kathryn Wagner.  Dr. Wagner, Director of the Center for Genetic Muscle Disorders at the Kennedy Krieger Institute and Professor of Neurology and Neuroscience at the Johns Hopkins School of Medicine, will investigate “Targeting Mss51 as…