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Coalition to Cure Calpain 3 provides support for promising research into finding treatments or a cure for limb-girdle muscular dystrophy, type 2A/Calpainopathy (LGMD2A).  The unrelenting nature of this disease takes its victims from full mobility to a wheelchair within 11-28 years after the onset of symptoms. LGMD2A attracts significantly fewer research dollars than other forms of muscular dystrophy and thus fewer researchers working to understand the disease and discover a cure.

The sole focus of C3 is on supporting researchers rather than on providing services to those who have the disease. Thus, all of the funds that are raised go directly into research labs, into bringing researchers together to exchange ideas and collaborate, and into supporting a patient database which would give researchers a list of people to contact about clinical trials of promising therapies.

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Want to help fund the next C3 research project? Click here to learn more about donating to the "C3 Adopt A Research Project"

Coalition to Cure Calpain 3 (EIN #90-0616879) is a 501 (c)(3) tax-exempt public charity.  As such, all donations are fully tax deductible. Download our IRS determination letter here.



"Calpain 3 LGMD2A is among the most common of the muscular dystrophies, but research on the pathophysiology and existence of clinical trials is woefully underrepresented. From the limited amount we know about Calpain 3 deficiency, it seems to be one of the most 'curable' of the muscular dystrophies.”

Eric Hoffman, PhD
Download biography here

“LGMD2A is caused by mutations in an enzyme called calpain 3. This mutation is vastly different from most of the other muscular dystrophies that involve mutations in structural proteins. Thus, it is absolutely essential that C3 exists to specifically fund research and treatment of calpainopathies.”

Melissa Spencer, PhD
Download biography here


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